Chronic Pain: When the Alarm System Becomes a Siren
- Nathanial Harnett
- Feb 17
- 2 min read
Updated: Feb 17

Chronic pain, unlike the acute pain you feel after stubbing your toe, is a complex issue that persists for longer than 12 weeks. It can significantly impact your daily life and well-being. To understand chronic pain, we need to delve into the changes happening within your nervous system and body.
The IASP Definition of Pain:
According to the International Association for the Study of Pain (IASP), pain is an "unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage." This definition highlights two key aspects of pain:
Sensory: Pain involves the activation of pain receptors in your body that send signals to the brain.
Emotional: Pain is not just a physical sensation; it also has emotional and psychological components like anxiety and fear.
Changes in the Nervous System with Chronic Pain:
Chronic pain disrupts the normal pain processing pathways in your nervous system. Here's a breakdown of some key changes:
Peripheral Sensitization: Increased sensitivity of pain receptors in the affected area, leading to heightened responses to even minor stimuli.
Central Sensitization: Changes in the central nervous system (brain and spinal cord) that amplify pain signals and make you more sensitive to pain throughout your body. This can explain why chronic pain can sometimes spread beyond the initial injury site.
Changes in the Body with Chronic Pain:
Chronic pain can also trigger various changes in your body, creating a vicious cycle:
Muscle Tension: Pain can lead to muscle tension and stiffness, further limiting movement and increasing discomfort.
Inflammation: Chronic pain can be associated with ongoing low-grade inflammation, contributing to pain sensitivity.
Reduced Activity: Fear of pain can lead to decreased physical activity, which can weaken muscles and worsen pain over time.
The NOI Group and Neuroplasticity Research
The NOI Group (Neurological Organization Implications) is a research group exploring the role of neuroplasticity in chronic pain. Neuroplasticity refers to the brain's ability to change and adapt throughout life. The NOI Group hypothesizes that chronic pain can lead to maladaptive changes in brain function, contributing to pain perception and sensitivity.
Their research focuses on understanding how these changes occur and exploring potential
therapeutic interventions that target neuroplasticity to promote pain relief and improved function in chronic pain patients.
Understanding these changes in the nervous system and body is crucial for developing effective treatment strategies for chronic pain. Treatments may address:
Reducing peripheral and central sensitization: Techniques like manual therapy and certain medications can help modulate pain signals.
Promoting healthy movement patterns: Physical therapy and exercise therapy can improve mobility, reduce muscle tension, and build strength.
Addressing psychological factors: Cognitive behavioral therapy (CBT) and CFT (cognitive functional therapy) can help manage negative thoughts and emotions associated with pain.
By combining various approaches, we can work towards breaking the cycle of chronic pain and helping individuals regain control of their lives.
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